Gelar Karya P5 “Bangunlah Jiwa Raganya” yang digelar oleh SMP Darul Mukmin pada 21-22 November 2024 menjadi bukti nyata implementasi pendidikan merdeka dan pembelajaran mendalam atau deep learning. Dengan tema Sehat Jiwaku, Kuat Ragaku, Barokah Ilmuku, kegiatan ini dirancang untuk melatih siswa dalam berpikir kritis, kreatif, serta bertanggung jawab terhadap diri sendiri dan lingkungannya.
Dalam paradigma pendidikan merdeka, siswa tidak hanya menjadi penerima informasi, tetapi juga pencipta pengetahuan. Kegiatan ini memberikan mereka kebebasan untuk mengeksplorasi berbagai gagasan yang diwujudkan melalui karya seni, drama, dan olahraga tradisional. Drama bertema kesehatan mental yang dipentaskan siswa menjadi salah satu daya tarik utama. Melalui pertunjukan ini, siswa menunjukkan kemampuan mereka dalam memahami, menganalisis, dan menyampaikan pesan tentang pentingnya menjaga keseimbangan jiwa dan raga.
Aspek pembelajaran mendalam terlihat jelas dalam sesi team building yang difasilitasi oleh guru pramuka. Dalam sesi ini, siswa dilatih untuk bekerja sama, mengatasi tantangan bersama, dan memperkuat kepercayaan diri. Proses ini tidak hanya mengajarkan keterampilan sosial, tetapi juga menanamkan nilai-nilai seperti kedisiplinan dan tanggung jawab. Setiap siswa belajar memahami peran mereka dalam kelompok, yang merupakan refleksi nyata dari prinsip gotong royong dalam Profil Pelajar Pancasila.
Yani Kosasih, S.Pd., Kepala Sekolah SMP Darul Mukmin, menyatakan bahwa kegiatan ini merupakan kesempatan penting untuk membangun kemandirian siswa. “Anak-anak belajar bertanggung jawab terhadap diri mereka sendiri dan juga teman-temannya. Ilmu yang mereka peroleh menjadi sesuatu yang dapat mereka tunjukkan kepada orang tua dan masyarakat,” ungkapnya. Hal ini menunjukkan bahwa pembelajaran berbasis proyek tidak hanya menghasilkan produk kreatif, tetapi juga membentuk karakter siswa secara holistik.
Keberhasilan kegiatan ini juga tidak lepas dari peran Wakil Kesiswaan, Drs. Kartono, dan Pembina OSIS, Ifan Manpaluthi, S.Pd., yang memastikan setiap tahap berlangsung dengan baik. Kolaborasi antara guru, siswa, dan tenaga pendidik lainnya menjadi kunci utama dalam menciptakan lingkungan belajar yang mendukung eksplorasi dan inovasi.
Gelar Karya P5 ini menunjukkan bagaimana pendidikan merdeka dan deep learning dapat diterapkan untuk menciptakan pengalaman belajar yang bermakna. Nilai-nilai seperti kerja sama, kemandirian, dan kreativitas yang terintegrasi dalam kegiatan ini menjadi bekal penting bagi siswa untuk menghadapi tantangan di masa depan. Lebih dari sekadar kegiatan sekolah, Gelar Karya P5 adalah langkah nyata dalam mencetak generasi Pelajar Pancasila yang kompeten, berkarakter, dan adaptif.
Referensi:
- Dewantara, Ki Hajar. Pendidikan dan Kebudayaan. Yogyakarta: Taman Siswa, 1962.
- Kemendikbudristek. “Merdeka Belajar dan Profil Pelajar Pancasila.” Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, 2023.
- Hattie, John. Visible Learning for Teachers: Maximizing Impact on Learning. Routledge, 2012.
Dokumentasi Kegiatan
Corchorusin-D, a saikosaponin-like compound
derived from Corchorus acutangulus, was studied in murine B16F10 melanoma cells-induced
xenograft tumor in mice (Mallick et al. 2013). The compound considerably inhibited tumor growth,
simultaneously increasing the survival price in mice.
Additional histological analysis of the tumors
showed a decrease mitotic index and a better degree of annexin V-FITC and propidium iodide (PI)-positive tumor cells indicating an induction of apoptosis
and a lower within the microvascular density
pointing to an antiangiogenic impact.
The end products of sterol and triterpenoid biosynthesis also manipulate the flux by way of these biosynthetic pathways
(Haralampidis et al., 2001b). Compared to
untreated controls the ratio of β-amyrin to cycloartenol reduced by ∼10-fold in G.
Also, in cell suspension cultures of Tabernaemontana divaricate, inhibition of the exercise of cycloartenol synthase resulted within the induction of β- and
α-amyrin synthases, which in turn elevated flux via the triterpenoid pathway (van der Heijden et al.,
1989).
The complexity of saponin chemistry possibly thought-about
as a gap for many scientists and researchers to know the relationship between the chemical construction and its
medical or pharmaceutical behavior. Recently, the increase in demand of
saponin functions was observed due to varied biological, medicinal, and
pharmaceutical actions. Therefore, this current evaluate article provides detailed details about the
chemistry of saponin, especially triterpenoid saponin.
Li and associates developed a concise and sensible synthetic
route for the synthesis of a number of furostane-type saponins
from readily accessible 16β-acetoxy-22-oxo-cholestanic derivatives, which can be applied to SAR research.
The biological assay outcomes demonstrated that funlioside B is a promising lead for α-glucosidase inhibition (Table 1)
[69]. Furostane-type saponins are characterised by a hemiketal ring and carbohydrate moiety attached to
the 3-OH and/or 26-OH of sapogenin. Straightforward conversion of furostane-saponins to spirostane-saponins and the microheterogeneity made
the isolation of furostane-saponins from
natural sources turn out to be problematic and tough.
Therefore, a number of chemical works have been established for the synthesis
of furostane-type saponins using 26-hydroxy-16,
22-dioxo-cholestan as a building block, providing efficient instruments to increase SAR knowledge
for medicinal chemistry analysis [124,125,126,127].
Miscellaneous bioactivities of saponins isolated from
Dracaena and Sansevieria species. A Each terresides A (75) and B (23) are known compounds; in reference [48] authors didn’t indicate whether one or each
saponins had been isolated from D. The organic properties of saponins within the context of their ecological functions
and business functions are mentioned under. Saponins have eco-friendly functions in agriculture, acting as a substitute for artificial chemical substances for pest management by disrupting the cell membranes of insects and fungi.
They additionally play a job in creating biodegradable detergents and surfactants, lowering harm to the surroundings and human health.
While saponins provide super health advantages when consumed appropriately, excessive intake or improper consumption can lead to adverse
effects. High concentrations could cause digestive issues,
hinder the absorption of significant vitamins, and doubtlessly cause toxicity.
Additionally, the conjugation of ginsenoside Rh2 onto
polymer-functionalized zinc oxide nanocomposites generated water-dispersible materials
able to absorbing, scattering, and reflecting UV radiation, exemplifying their potential as nanomaterial
sun-blockers [61]. Pakulski and Strnad developed a sequence
of lupane- (modified at 3-OH position) and homolupane-based (modified at 28-COOH position) saponins, together with 3-O-glycoside, 28-COO-glycoside, 28-COO-thioglycoside, 28-COO-selenoglycoside and bidesmosidic
saponins. Nonetheless, all the compounds tested
had been both poorly cytotoxic to cancer cells, or poorly selective for most cancers cells over normal cells [55,98,ninety nine,a hundred,101].
Ursolic acid is a pentacyclic triterpenoid largely isolated
from berries, especially cranberries (Vaccinium macrocarpon), and other Vaccinium species [83].
Multiple organic activities are discovered
within the artificial ursolic acid derivatives (Figure 4), corresponding to
antiviral, cardioprotective, anticancer and anti-inflammatory results (Table 1) [84,85].
Song and co-workers synthesized a series
of 3-O-β-chacotriosyl ursolic acid serving as entry inhibitors of H5N1,
and the SAR analysis demonstrated an analogous statement to
their research of the derivatives of oleanolic acid.
And have served as an oral treatment for heart failure and cardiac
arrhythmia for centuries [128]. The cardioprotective exercise of CG originates from their binding and inhibition of
the cardiac myocyte membrane Na+/K+-ATPase, reducing the heart burden [129].
Several cardiac glycosides are now under investigation in Section I and II scientific trials for strong tumor treatments and revealed
a promising safety and efficacy [134]. A Quantity Of organic results of saponins are attributable
to their capacity to permeabilize cell membranes. The hemolytic exercise of saponins is
a consequence of the formation of stable
pores within the erythrocyte membrane (Seeman, 1967). The membrane permeabilizing activity of saponins is correlated with their amphipathic nature and
affected by the aglycone construction, saccharide chain size,
sugar variants within the glycosidic chain and kind of aglycone–sugar and sugar–sugar linkages.
We also reviewed the features and distribution of steroidal saponins in vegetation and discussed the molecular evolutionary mechanism of steroidal saponin biosynthesis.
The industrial uses and potential of saponins are discussed with respect
to construction and exercise, highlighting the undoubted value of these molecules as therapeutics.
Steroidal saponins, outstanding bioactive constituents
present in monocot crops, primarily comprise sugars and glycosides.
They considerably contribute to the domain of pure product chemistry due to their
profound pharmacological attributes and demonstrated efficacy in treating a plethora of illness.
It is noteworthy that increasingly in vivo studies are being
carried out on saponins and their semisynthetic derivatives or
novel formulations. Studies focused on the structure–activity relationship assist to know the significance
of specific structural features within a wide array of saponin types.
In the time scope of this review, a large quantity of such reports have appeared, which confirmed some already known correlations and established novel ones.
Nevertheless, this issue requires additional analysis, as specifically designed SAR research that compare saponins
that comprise the identical sugar chain however differ
within the major kind of the aglycone (OT vs.
UT vs. LT) are still very uncommon. A novel formulation to target
the anticancer agent extra successfully in tumor tissue and concurrently lower its toxicity was designed for saikosaponin-d (SsD).
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